Fig. 4.

SiNPs inhibit TRPV4 activation in mTEC. a, b, c, d Effects of the TRPV4 agonist GSK1016790A on the [Ca²⁺]_i in the absence (a, n = 127) or in the presence of SiNPs 1 μg/ml (b, n = 243) and 3000 μg/ml (c, n = 349). The thick continuous traces correspond to the average responses and the thin dashed traces correspond to the mean plus/minus the standard errors. d Average amplitude of responses to 10 nM GSK1016790A when applied in the presence of SiNPs at different concentrations. The solid line represents a fit with a Hill function (see Methods)