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. 2017 Nov 3;14:43. doi: 10.1186/s12989-017-0224-2

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — The pre-application time of SiNP has no significant effect on the magnitude of inhibition of TRPV4 response to GSK1016790A. a Effects of the TRPV4 agonist GSK1016790A on the [Ca²⁺]_i of HEK293T cells transfected with mouse TRPV4. b, c, d TRPV4 responses to GSK1016790A after pre-application of SiNPs during different periods (0, 3 and 10 min for panels b, c and d, respectively). The thick continuous traces correspond to the average responses and the thin dashed traces correspond to the mean plus/minus the standard errors. The black and grey traces correspond to cells with high or low basal [Ca²⁺]_i, respectively (see text). e, f Average amplitude of responses to 2 min applications of GSK1016790A in control and after pre-application of SiNPs for different periods (n = 105 - 385)