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DUB inhibitors for preclinical application in CSC-targeted therapy
| Inhibitors | Targeted DUBs | CSC type | References |
|---|---|---|---|
| Pimozide | USP1 | Osteosarcoma, glioblastoma | [25, 83] |
| ML323 | USP1 | ||
| P5091 | USP7, USP47 | Neural, glioblastoma, multiple myeloma | [57, 85–87] |
| P22077 | USP7, USP47 | ||
| WP1130 | USP9x, USP5, UCHL1, USP14, UCH37 | Liver, breast cancer | [72, 73] |
| IU1 | USP14 | Gastric, multiple myeloma | [74, 75] |
| b-AP15 | USP14, UCHL5 | ||
| VLX1570 | USP14 | ||
| LDN-57444 | UCHL1, UCHL3 | Prostate | [76] |
| TCID | UCHL3, UCHL5 | Multiple myeloma | [84] |
