. Author manuscript; available in PMC: 2018 Nov 1.

Published in final edited form as: Am J Obstet Gynecol. 2017 Jul 20;217(5):587.e1–587.e10. doi: 10.1016/j.ajog.2017.07.022

Table 3.

Example of differentially expressed genes in fetuses with myelomeningocele with significant roles in brain and spinal cord development and function identified by IPA (* novel genes associated with myelomeningocele)

Molecular function	Genes
Planer cell polarity	WNT5A (↓ 3.7 folds), PRICKLE2 (↓ 3.9)
Spinal ventral-dorsal regionalization	WNT1 (↓ 1.7), WNT5A (↓ 3.7), SKI* (↓ 8.2), GPR37* (↓ 3.9), HNF1B* (↑ 4.4)
Neuronal differentiation	GFAP (↑ 79.6), C1orf61* (↑ 22.4)
Dorsal horn development	NEUROD6* (↓ 1.9), ZEB1* (↑ 22.5)
Axonal growth, guidance	GAP43* (↑ 44.0), ACAP1* (↓ 9.0), SEMA5A* (↓ 8.1), DRAXIN* (↓ 1.7)
Schwann cell development	POU3F1* (↓ 6.5)
Motor neuron survival	PQBP1* (↓ 4.8)
Synaptic transmission, plasticity	SERPINB6 (↑ 172.9), TSHZ3 (↓ 6.5), ERBB3* (↓ 1.8)
Neuronal injury, repair	GFAP (↑ 79.6), GAP43* (↑ 44.0), HNF1B* (↑ 4.4), HMGB1* (↑ 2.3)