Table 3.
Performance of uterine artery Doppler measurements between 16 weeks 0 days and 22 weeks 6 days in the prediction of birth weight <5th percentile for gestational age at delivery.
| Thresholds for UAD measurements | N | Sens | Spec | PPV | NPV | LR+ | LR− | AUC |
|---|---|---|---|---|---|---|---|---|
| Early diastolic notch | ||||||||
| Present | 1458 | 29.9% | 82.4% | 7.3% | 96.2% | 1.70 | 0.85 | 0.56 |
| Depth of diastolic notch | ||||||||
| ≥10 cm/sec | 130 | 2.5% | 98.4% | 6.9% | 95.6% | 1.59 | 0.99 | 0.50 |
| ≥5 cm/sec | 795 | 15.9% | 90.4% | 7.2% | 95.8% | 1.65 | 0.93 | 0.53 |
| ≥1 cm/sec | 1448 | 29.6% | 82.5% | 7.3% | 96.2% | 1.69 | 0.85 | 0.56 |
| Resistance index (RI) | ||||||||
| ≥0.58 (suggested) | 2121 | 44.4% | 74.4% | 7.5% | 96.6% | 1.74 | 0.75 | 0.59 |
| ≥0.59 (optimized) | 1893 | 41.6% | 77.3% | 7.9% | 96.6% | 1.83 | 0.76 | 0.59 |
| Pulsatility index (PI) | ||||||||
| ≥1.60 (suggested) | 249 | 9.5% | 97.2% | 13.7% | 95.8% | 3.39 | 0.93 | 0.53 |
| ≥0.98 (optimized) | 2101 | 45.5% | 74.7% | 7.8% | 96.7% | 1.80 | 0.73 | 0.60 |
UAD = uterine artery Doppler, N = number positively screened, Sens = sensitivity, Spec = specificity, PPV = positive predictive value, NPV = negative predictive value, LR+ = positive likelihood ratio, LR− = negative likelihood ratio, AUC = area under the receiver operator characteristic curve. “Suggested” thresholds are from the literature. “Optimized” thresholds are those maximizing the sum of sensitivity and specificity on the primary outcome, fetal growth restriction.