Table 4.
Performance of uterine artery Doppler measurements between 16 weeks 0 days and 22 weeks 6 days in the prediction of secondary outcomes (preeclampsia/antepartum gestational hypertension, spontaneous preterm birth, and stillbirth).
| Thresholds for UAD measurements | N | Sens | Spec | PPV | NPV | LR+ | LR− | AUC | |
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Early diastolic notch | |||||||||
|
| |||||||||
| Present | GHTN | 1462
|
24.3% | 82.7% | 17.3% | 88.0% | 1.40 | 0.92 | 0.53 |
| SPTB | 1463
|
17.4% | 81.8% | 4.7% | 95.0% | 0.95 | 1.01 | 0.50 | |
| SB | 1464 | 26.5% | 81.8% | 0.6% | 99.6% | 1.46 | 0.90 | 0.54 | |
|
| |||||||||
| Depth of diastolic notch | |||||||||
|
| |||||||||
| ≥10 cm/sec | GHTN | 131
|
2.3% | 98.5% | 18.3% | 87.1% | 1.50 | 0.99 | 0.50 |
| SPTB | 131
|
2.3% | 98.4% | 6.9% | 95.1% | 1.42 | 0.99 | 0.50 | |
| SB | 131 | 0.0% | 98.4% | 0.0% | 99.6% | 0.00 | 1.02 | 0.49 | |
|
| |||||||||
| ≥5 cm/sec | GHTN | 796
|
13.4% | 90.6% | 17.6% | 87.5% | 1.43 | 0.96 | 0.52 |
| SPTB | 796
|
10.1% | 90.1% | 5.0% | 95.1% | 1.02 | 1.00 | 0.50 | |
| SB | 797 | 8.8% | 90.1% | 0.4% | 99.6% | 0.89 | 1.01 | 0.49 | |
|
| |||||||||
| ≥1 cm/sec | GHTN | 1452
|
24.1% | 82.8% | 17.3% | 88.0% | 1.40 | 0.92 | 0.53 |
| SPTB | 1453
|
17.4% | 81.9% | 4.7% | 95.0% | 0.96 | 1.01 | 0.50 | |
| SB | 1454 | 26.5% | 82.0% | 0.6% | 99.6% | 1.47 | 0.90 | 0.54 | |
|
| |||||||||
| Resistance index (RI) | |||||||||
|
| |||||||||
| ≥0.58 (suggested) | GHTN | 2125
|
33.3% | 74.6% | 16.3% | 88.2% | 1.31 | 0.89 | 0.54 |
| SPTB | 2125
|
24.2% | 73.5% | 4.5% | 94.9% | 0.91 | 1.03 | 0.49 | |
| SB | 2126 | 38.2% | 73.6% | 0.6% | 99.6% | 1.45 | 0.84 | 0.56 | |
|
| |||||||||
| ≥0.59 (optimized) | GHTN | 1897
|
31.0% | 77.5% | 17.0% | 88.3% | 1.38 | 0.89 | 0.54 |
| SPTB | 1897
|
21.2% | 76.3% | 4.4% | 94.9% | 0.89 | 1.03 | 0.49 | |
| SB | 1898 | 32.4% | 76.5% | 0.6% | 99.6% | 1.37 | 0.88 | 0.56 | |
|
| |||||||||
| Pulsatility index (PI) | |||||||||
|
| |||||||||
| ≥1.60 (suggested) | GHTN | 250
|
5.3% | 97.2% | 22.0% | 87.3% | 1.89 | 0.97 | 0.51 |
| SPTB | 249
|
3.3% | 96.9% | 5.2% | 95.1% | 1.06 | 1.00 | 0.50 | |
| SB | 250 | 5.9% | 96.9% | 0.8% | 99.6% | 1.90 | 0.97 | 0.51 | |
|
| |||||||||
| ≥0.98 (optimized) | GHTN | 2106
|
33.4% | 74.8% | 16.5% | 88.3% | 1.33 | 0.89 | 0.54 |
| SPTB | 2106
|
23.2% | 73.7% | 4.4% | 94.9% | 0.88 | 1.04 | 0.48 | |
| SB | 2107 | 44.1% | 73.9% | 0.7% | 99.7% | 1.69 | 0.76 | 0.59 | |
UAD = uterine artery Doppler, N = number positively screened (numbers vary slightly with the outcome due to availability of the information needed to define the outcome), Sens = sensitivity, Spec = specificity, PPV = positive predictive value, NPV = negative predictive value, LR+ = positive likelihood ratio, LR− = negative likelihood ratio, AUC = area under the receiver operator characteristic curve, GHTN = preeclampsia/ antepartum gestational hypertension, SPTB = spontaneous preterm birth, SB = stillbirth. “Suggested” thresholds are from the literature. “Optimized” thresholds are those maximizing the sum of sensitivity and specificity on the primary outcome, fetal growth restriction.