Table 2.

Subgroup associations of crepitus with incident tibiofemoral SOA 1 year after crepitus assessment

		Incident SOA	Unadjusted Odds Ratio for Incident SOA	Adjusted Odds Ratio for Incident SOA*
People with ROA but without symptoms at baseline.	2973 observations from 1085 people	Total cases = 488
(+ROA, −Sx)
	Never	251/1952 (12.9%)	Ref	Ref
	Rarely	63/327 (19.3%)	1.6 (1.2 – 2.2)	1.6 (1.2 – 2.1)
	Sometimes	98/428 (22.9%)	2.0 (1.5 – 2.6)	1.9 (1.4 – 2.5)
	Often	43/153 (28.1%)	2.6 (1.8 – 3.8)	2.5 (1.7 – 3.6)
	Always	33/113 (29.2%)	2.8 (1.8 – 4.2)	2.8 (1.8 – 4.4)
			p for trend < 0.0001	p for trend < 0.0001
People without ROA but with symptoms at baseline.	2137 observations from 660 people	Total Cases = 67
(−ROA, +Sx)
	Never	30/1049 (2.9%)	Ref	Ref
	Rarely	6/239 (2.5%)	0.9 (0.4 – 2.1)	1.0 (0.4 – 2.4)
	Sometimes	15/485 (3.1%)	1.1 (0.6 – 2.0)	1.0 (0.5 – 2.1)
	Often	7/210 (3.3%)	1.2 (0.5 – 2.7)	1.2 (0.5 – 2.9)
	Always	9/154 (5.8%)	2.1 (1.0 – 4.6)	1.8 (0.8 – 4.2)
			p for trend = 0.2	p for trend = 0.3
People without ROA and symptoms at baseline.	6127 observations from 1750 people	Total Cases = 81
(−ROA, −Sx)
	Never	51/4312 (1.2%)	Ref	Ref
	Rarely	10/647 (1.5%)	1.3 (0.7 – 2.6)	1.4 (0.7 – 2.7)
	Sometimes	17/788 (2.2%)	1.8 (1.1 – 3.2)	1.8 (1.0 – 3.3)
	Often	2/263 (0.8%)	0.6 (0.2 – 2.6)	0.8 (0.2 – 3.2)
	Always	1/117 (0.9%)	0.7 (0.1 – 5.3)	0.8 (0.1 – 6.2)
			p for trend = 0.3	p for trend = 0.3

^*adjusted for age, sex, and BMI.