Table 4.

Subgroup associations of crepitus with incident tibiofemoral SOA over 4 years

		Incident SOA	Unadjusted Odds Ratio for Incident SOA	Adjusted Odds Ratio for Incident SOA*
People with ROA but without symptoms at baseline.	1085 people	Total cases = 488
(+ROA, −Sx)
	Never	261/669 (39.0%)	Ref	Ref
	Rarely	63/127 (49.6%)	1.5 (1.1–2.3)	1.5 (1.0–2.3)
	Sometimes	84/171 (49.1%)	1.5 (1.1–2.1)	1.5 (1.0–2.1)
	Often	48/77 (62.3%)	2.6 (1.6–4.2)	2.4 (1.5–3.9)
	Always	32/41 (78.0%)	5.6 (2.6–11.8)	5.5 (2.5–11.8)
			p for trend < 0.0001	p for trend < 0.0001
People without ROA but with symptoms at baseline.	660 people	Total Cases = 67
(ROA, +Sx)
	Never	29/298 (9.7%)	Ref	Ref
	Rarely	7/67 (10.5%)	1.1 (0.5–2.6)	1.2 (0.5–2.8)
	Sometimes	15/169 (8.9%)	0.9 (0.5–1.7)	0.9 (0.5–1.8)
	Often	7/72 (9.7%)	1.0 (0.4–2.4)	1.1 (0.4–2.7)
	Always	9/54 (16.7%)	1.9 (0.8–4.2)	2.0 (0.8–4.8)
			p for trend = 0.4	p for trend = 0.4
People without ROA and symptoms at baseline.	1750 people	Total Cases = 81
(−ROA, −Sx)
	Never	48/1228 (3.9%)	Ref	Ref
	Rarely	11/197 (5.6%)	1.5 (0.7–2.9)	1.5 (0.8–3.0)
	Sometimes	15/221 (6.8%)	1.8 (1.0–3.3)	1.9 (1.0–3.4)
	Often	6/80 (7.5%)	2.0 (0.8–4.8)	2.2 (0.9–5.4)
	Always	1/24 (4.2%)	1.1 (0.1–8.1)	1.1 (0.1–8.7)
			p for trend=0.04	p for trend =0.03

^*adjusted for age, sex, and BMI.