Table 2.
Univariate and Multivariate Analysis for Parameters Associated with pCR in the Discovery Dataset
| Characteristics | n | pCR | Univariate Analysis |
Multivariate Analysis |
||||
|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P | OR | 95% CI | P | |||
| Age | ||||||||
| ≤50 | 268 | 60 | 1 | |||||
| >50 | 220 | 39 | 0.75 | 0.47-1.17 | .204 | |||
| Unknown | ||||||||
| ER | ||||||||
| Negative | 200 | 69 | 1 | |||||
| Positive | 287 | 30 | 0.22 | 0.14-0.35 | 6.20e-10 | 0.70 | 0.38-1.28 | .25115 |
| Unknown | 1 | |||||||
| HER2 | ||||||||
| Negative | 466 | 93 | 1 | |||||
| Positive | 5 | 2 | 2.67 | 0.35-16.36 | .285 | |||
| Unknown | 17 | 4 | ||||||
| cT | ||||||||
| T0-2 | 274 | 58 | 1 | |||||
| T3-4 | 214 | 41 | 0.88 | 0.56-1.38 | .584 | |||
| Unknown | 0 | |||||||
| cN | ||||||||
| Negative | 154 | 28 | 1 | |||||
| Positive | 334 | 71 | 1.21 | 0.75-2.00 | .433 | |||
| Unknown | ||||||||
| Grade | ||||||||
| 1-2 | 201 | 13 | 1 | |||||
| 3 | 252 | 77 | 6.36 | 3.53-12.36 | 5.73e-09 | 2.07 | 1.02-4.40 | .04922 |
| Unknown | 35 | |||||||
| lncRNA score | ||||||||
| Low score | 286 | 22 | 1 | |||||
| High score | 202 | 77 | 7.39 | 4.47-12.68 | 4.41e-14 | 2.74 | 1.40-5.51 | .00373 |
| Intrinsic subtype | ||||||||
| Luminal A | 124 | 2 | 1 | |||||
| Others | 364 | 97 | 25.78 | 7.99-157.88 | 6.76e-06 | 6.91 | 1.50-50.6 | .02463 |
| Oncotype DX | ||||||||
| Low & medium score | 80 | 2 | 1 | |||||
| High score | 408 | 97 | 12.16 | 3.74-74.79 | 5.73e-04 | 1.41 | 0.33-9.76 | .67782 |
| Gene70 | ||||||||
| Low score | 82 | 3 | 1 | |||||
| High score | 406 | 96 | 8.15 | 2.96-33.77 | 4.63e-04 | 0.92 | 0.25-4.49 | .91205 |
| GGI | ||||||||
| Low score | 195 | 13 | 1 | |||||
| High score | 293 | 86 | 5.82 | 3.25-11.24 | 2.15e-08 | 0.94 | 0.41-2.23 | .88345 |