Table 3.
Univariate and Multivariate Analysis for Predicting Parameters Associated with pCR in the Validation Dataset
| Characteristics | n | pCR | Univariate Analysis |
Multivariate Analysis |
||||
|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P | OR | 95% CI | P | |||
| Age | ||||||||
| ≤50 | 287 | 58 | 1 | |||||
| >50 | 264 | 52 | 0.97 | 0.64-1.47 | .881 | |||
| Unknown | 2 | 0 | ||||||
| ER | ||||||||
| Negative | 249 | 83 | 1 | 1 | ||||
| Positive | 304 | 27 | 0.19 | 0.12-0.31 | 1.51e-11 | 0.28 | 0.15-0.50 | 3.79e-05 |
| Unknown | 0 | 0 | ||||||
| HER2 | ||||||||
| Negative | 463 | 81 | 1 | 1 | ||||
| Positive | 85 | 29 | 2.00 | 1.25-3.26 | 4.33e-3 | 2.18 | 1.19-4.00 | .01147 |
| Unknown | 1 | 0 | ||||||
| cT | ||||||||
| T0-2 | 316 | 66 | 1 | |||||
| T3-4 | 234 | 44 | 0.88 | 0.57-1.34 | .546 | |||
| Unknown | 3 | 0 | ||||||
| cN | ||||||||
| Negative | 159 | 21 | 1 | |||||
| Positive | 345 | 66 | 1.56 | 0.93-2.71 | .101 | |||
| Unknown | 49 | 23 | ||||||
| Grade | ||||||||
| 1-2 | 225 | 18 | 1 | 1 | ||||
| 3 | 271 | 80 | 4.84 | 2.86-8.60 | 1.67e-08 | 1.58 | 0.82-3.11 | .17662 |
| Unknown | 57 | 12 | ||||||
| lncRNA score | ||||||||
| Low score | 317 | 25 | 1 | 1 | ||||
| High score | 236 | 85 | 6.57 | 4.10-10.89 | 3.6e-14 | 4.17 | 2.18-8.36 | 2.97e-05 |
| Intrinsic Subtype | ||||||||
| Luminal A | 122 | 5 | 1 | 1 | ||||
| Others | 431 | 105 | 7.54 | 3.31-21.73 | 1.74e-05 | 0.99 | 0.28-3.96 | .98660 |
| Oncotype DX | ||||||||
| Low & medium score | 81 | 3 | 1 | 1 | ||||
| High score | 472 | 107 | 7.62 | 2.77-31.51 | 6.87e-04 | 1.07 | 0.27-5.42 | .92960 |
| Gene70 | ||||||||
| Low score | 101 | 5 | 1 | 1 | ||||
| High score | 452 | 105 | 5.81 | 2.54-16.80 | 1.93e-04 | 0.86 | 0.27-3.04 | .80190 |
| GGI | ||||||||
| Low score | 226 | 21 | 1 | 1 | ||||
| High score | 327 | 89 | 3.65 | 2.23-6.22 | 6.74e-07 | 1.35 | 0.65-2.89 | .43185 |