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. 2017 Nov 2;10(6):988–997. doi: 10.1016/j.tranon.2017.09.005

Table 4.

Association between Clinicopathological Parameters and LRS in the Discovery and Validation Dataset

Characteristics Discovery Set
Validation Set
LRS Low LRS High P LRS Low LRS High P
n 286 202 317 236
Age
 ≤50 154 114 168 119
 >50 132 88 .6356 148 116 .6165
 Unknown 0 0 1 1
ER
 Negative 43 157 85 164
 Positive 242 45 <2.2e-16 232 72 <2.2e-16
 Unknown 1 0 0 0
HER2
 Negative 275 191 277 190
 Positive 1 4 .1651 40 45 .0474
 Unknown 10 7 0 1
cT
 T0-2 174 100 186 130
 T3-4 112 102 .01673 128 106 .3749
 Unknown 0 0 3 0
cN
 Negative 102 52 104 55
 Positive 184 150 .02615 202 143 .1717
 Unknown 0 0 10 39
Grade
 1-2 174 27 176 49
 3 97 155 <2.2e-16 101 170 <2.2e-16
 Unknown 15 20 40 17
Intrinsic subtype
 Luminal A 135 2 117 5
 Others 151 200 <2.2e-16 200 231 <2.2e-16
Oncotype DX
 Low & medium score 79 1 77 4
 High score 207 201 4.211e-15 240 232 2.647e-13
Gene70
 Low score 81 1 96 5
 High score 205 201 1.527e-15 221 231 <2.2e-16
GGI
 Low score 180 15 188 38
 High score 106 187 <2.2e-16 129 198 <2.2e-16
pCR status
 pCR 22 77 25 85
 Non-pCR 264 125 <2.2e-16 292 151 <2.2e-16