Table 4.
Association between Clinicopathological Parameters and LRS in the Discovery and Validation Dataset
| Characteristics | Discovery Set |
Validation Set |
||||
|---|---|---|---|---|---|---|
| LRS Low | LRS High | P | LRS Low | LRS High | P | |
| n | 286 | 202 | 317 | 236 | ||
| Age | ||||||
| ≤50 | 154 | 114 | 168 | 119 | ||
| >50 | 132 | 88 | .6356 | 148 | 116 | .6165 |
| Unknown | 0 | 0 | 1 | 1 | ||
| ER | ||||||
| Negative | 43 | 157 | 85 | 164 | ||
| Positive | 242 | 45 | <2.2e-16 | 232 | 72 | <2.2e-16 |
| Unknown | 1 | 0 | 0 | 0 | ||
| HER2 | ||||||
| Negative | 275 | 191 | 277 | 190 | ||
| Positive | 1 | 4 | .1651 | 40 | 45 | .0474 |
| Unknown | 10 | 7 | 0 | 1 | ||
| cT | ||||||
| T0-2 | 174 | 100 | 186 | 130 | ||
| T3-4 | 112 | 102 | .01673 | 128 | 106 | .3749 |
| Unknown | 0 | 0 | 3 | 0 | ||
| cN | ||||||
| Negative | 102 | 52 | 104 | 55 | ||
| Positive | 184 | 150 | .02615 | 202 | 143 | .1717 |
| Unknown | 0 | 0 | 10 | 39 | ||
| Grade | ||||||
| 1-2 | 174 | 27 | 176 | 49 | ||
| 3 | 97 | 155 | <2.2e-16 | 101 | 170 | <2.2e-16 |
| Unknown | 15 | 20 | 40 | 17 | ||
| Intrinsic subtype | ||||||
| Luminal A | 135 | 2 | 117 | 5 | ||
| Others | 151 | 200 | <2.2e-16 | 200 | 231 | <2.2e-16 |
| Oncotype DX | ||||||
| Low & medium score | 79 | 1 | 77 | 4 | ||
| High score | 207 | 201 | 4.211e-15 | 240 | 232 | 2.647e-13 |
| Gene70 | ||||||
| Low score | 81 | 1 | 96 | 5 | ||
| High score | 205 | 201 | 1.527e-15 | 221 | 231 | <2.2e-16 |
| GGI | ||||||
| Low score | 180 | 15 | 188 | 38 | ||
| High score | 106 | 187 | <2.2e-16 | 129 | 198 | <2.2e-16 |
| pCR status | ||||||
| pCR | 22 | 77 | 25 | 85 | ||
| Non-pCR | 264 | 125 | <2.2e-16 | 292 | 151 | <2.2e-16 |