Figure 7.

The effect of i.v. injection of lorglumide on CT nerve responses to taste stimuli. (A) Typical examples of CT nerve responses to 100 mM NH₄Cl (NH₄Cl), 20 mM quinine-HCl (QHCl), 100 mM NaCl (NaCl), 100 mM monopottasium glutamate (MPG), 300 mM sucrose (Suc), and 10 mM HCl (HCl) before (0 min), 10 min, and 60 min after administration of 10 μg/Kg b.w of lorglumide in a WT mouse. Bars indicate taste stimulation (30 s). (B) Time-dependent changes in CT nerve responses to 300 mM Suc (black), 100 mM NaCl (blue), 10 mM HCl (red), 100 mM MSG (green), and 20 mM QHCl (magenta) 0–120 min after administration of 10 μg/Kg b.w of lorglumide in WT mice (n = 6–7). (C) Dose-dependent effect of lorglumide administration on CT nerve responses to 20 mM QHCl in WT mice (n = 5–7). CT nerve responses to QHCl 5–20 min after administration of 0–10 μg/Kg b.w. of lorglumide were normalized to those before administration. Values indicated are mean ± SEM. Statistical differences were analyzed by one way ANOVA (Supplemental Table 3) and post-hoc Tukey HSD test (^*P < 0.05, ^**P < 0.01).