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. 2017 Oct 31;11:335. doi: 10.3389/fncel.2017.00335

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Copyright © 2017 Li, Jia, Yue, Yang, Huang, Verkhratsky and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Acute treatment with fluoxetine induced extracellular-regulated kinase (ERK)_1/2 and AKT phosphorylation in astrocytes. Cells were incubated for 20 min in the absence of any drug (0 μM fluoxetine, control) or in the presence of 0.1, 0.5, 1, 5, or 10 μM fluoxetine. (A) Immunoblot from a representative experiment. Similar results were obtained from three independent experiments. Average ERK phosphorylation was quantitated as ratios between p-ERK₁ and ERK₁ and between p-ERK₂ and ERK₂, or average AKT phosphorylation was quantitated as ratio between p-AKT and AKT (B). SEM values are indicated by vertical bars. *Indicates statistically significant (P < 0.05) difference from 0, 0.1, 0.5 and 1 μM fluoxetine; **indicates statistically significant (P < 0.05) difference from all other groups but not from each other.