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. 2017 Oct 31;11:335. doi: 10.3389/fncel.2017.00335

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Copyright © 2017 Li, Jia, Yue, Yang, Huang, Verkhratsky and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of fluoxetine on the glycogen content requires ERK or AKT activation in astrocytes. Cells were incubated for 2 weeks without any drug (0 μM fluoxetine, control) or with 0.1, 0.5, 1, 5, or 10 μM fluoxetine in the presence of U0126, an inhibitor of MEK or LY294002, an inhibitor of PI3K. After the experiment glycogen was determined by measuring glucose content fluorometrically before and after breakdown of remaining glycogen in astrocytes. Average glycogen contents are indicated as percentages of those under control conditions. SEM values are indicated by vertical bars. *Indicates statistically significant (P < 0.05) difference from 0 and 0.1 μM groups but not from each other; **indicates statistically significant (P < 0.05) difference from 0, 0.1, 0.5 and 1 μM groups; ***indicates statistically significant (P < 0.05) difference from all other groups.