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Immobility time in the force swimming test (FST) of three genotype in both female and male mice treated by duloxetine. The immobility time in the FST of three genotype in female mice (A) and male mice (B) treated by duloxetine. ##Indicates P < 0.01 compared to vehicle-treated, *indicate P < 0.05 and **P < 0.01 compared to wildtype (WT) mice mice. n = 6–7 mice/group.
