Figure 5.

Treatment with a carbon monoxide-releasing molecule recapitulates the antiviral effects of CoPP after HSV infection. Quantification of plaque forming units (PFU) after HSV-2 titration over (A). Vero and (B). HeLa cells treated with CORM-2 and inactivated CORM-2 (iCORM2). Virus-encoded GFP fluorescence (non-structural GFP reporter) determined by flow cytometry in (C). Vero and (D). HeLa cells infected with HSV at different MOIs at 20 h post-infection. Data are means ± SEM of three independent experiments. One-way ANOVA, and Tukey's multiple comparison test were used for statistical analyses (^*p < 0.05, ^**p < 0.01, ^***p < 0.001).