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. 2017 Oct 31;11:337. doi: 10.3389/fncel.2017.00337

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Copyright © 2017 Pratt, Kuljis, Homanics, He, Kolodieznyi, Dudem, Hollywood, Barth and Bruchez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Measurements of FAP-BKα motor effects and PC physiology. (A) Performance on the accelerating rotarod (6–60 × g over 300 s, 200 s sustained) segregated by genotype and trial number. (B) Performance on accelerating rotarod based on sex. (C) Measurements of stride length of WT, FAP-BKα Het and Hom littermates. (D) Measurements of mouse weight segregated by sex and genotype. ^∗∗P ≤ 0.01 based on sex (n = WT F: 4, M: 2; Het F: 5 F, M: 1; Hom F: 4, M: 1) (E) Example traces from spontaneously firing PCs in acute slices from WT, FAP-BKα Het, and FAP-BKα Hom mice. (F) Quantification of spontaneous spike rate in WT, FAP-BKα Het, and FAP-BKα Hom mice (n = WT: 4 mice, 19 PCs; Het: 4 mice, 9 PCs; Hom: 3 mice, 16 PCs).