Table 5.

BIS/BAS modulated regions during reappraisal in healthy and depressed groups.

Region of activation	Side	BA	MNI Coordinates			Cluster size	Z score
			x	y	z
A. POSITIVE (DETACH-ATTEND)
Control
[BIS]
Inferior frontal gyrus	R	47	46	22	−28	188	2.86
Middle frontal gyrus	R	10	32	54	−12	56	2.11
[BASR]
Inferior frontal gyrus	R	47	26	32	−14		3.56
Midbrain	R		4	−12	−20		3.44
[BASD]
Midbrain	R		0	−30	−12	104	2.04
MDD
[BIS]
Posterior cingulate	R	23	14	−58	16	1460	2.93
Middle frontal gyrus	R	9	42	22	26		2.02
B. NEGATIVE (DETACH-ATTEND)
Control
[BASD]
Medial frontal gyrus	R	10	6	56	−4	107	2.90
Anterior cingulate	L	32	−22	36	14	86	2.74
Midbrain	R		4	−24	−16	96	2.66
[BASR]
Hippocampus	L		−26	−46	8	385	2.45
Medial frontal gyrus	R	10	14	54	2	74	2.36
MDD
[BASD]
Middle frontal gyrus	L	9	−40	20	20		2.59
Middle frontal gyrus	R	9	42	28	22		2.32
[BASR]
Midbrain	L		0	−18	−6		2.23
Posterior cingulate	L	30	0	−62	14	88	2.20
C. POSITIVE (IMMERSE-ATTEND)
Control
[BASD]
Midbrain	R		4	−24	−16	96	2.66
[BASR]
Midbrain	R		6	−24	−14		2.53
Middle frontal gyrus	R	46	42	34	8	113	2.42
Cingulate gyrus	L	24	−6	4	24	110	2.36
Amygdala	L		−26	−4	−20	59	2.25
[BASF]
Middle frontal gyrus	R	10	40	40	−2	165	3.51
Medial frontal gyrus	R	10	22	52	2	89	2.46
Medial frontal gyrus	R	10	18	40	−18	84	2.41
MDD
[BASD]
Cingulate gyrus	R	24	2	−2	42	659	3.03
[BASF]
Amygdala	R		32	−12	−18		2.02
[BIS]
Medial frontal gyrus	L	9	−20	44	18	160	2.36
D. NEGATIVE (IMMERSE-ATTEND)
Control
[BIS]
Midbrain	L		−4	−8	−12	58	2.76
MDD
[BASD]
Middle frontal gyrus	L	9	−42	18	28	11,221	4.39
Lentiform nucleus	L		−26	−4	8		4.05
Inferior parietal lobule	R	40	44	−24	44	532	3.14

A one-sample t-test for each group and for each condition was performed, and BIS/BAS scores were entered as covariates of interest, which yielded whole-brain activation. All clusters were thresholded at P < 0.05 and AlphaSim-corrected with an extent of at least 54 voxels.