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. 2017 Aug 30;3(4):481–486. doi: 10.1016/j.trci.2017.08.004

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 3 — Input function (IF) evaluation for [¹⁸F]UCB-H tracer: (A) [¹⁸F]UCB-H in blood (MFB, measured full blood) and in plasma (S1, subject 1). Radioactivity in Becquerel per cubic centimeter (Bq/cc); (B) Mean unchanged [¹⁸F]UCB-H in plasma for the four participants. SD, standard deviation; (C) Image-derived input function (IDIF) scaled to match the plasma measures using the last three plasma values and measured plasma IF (plasma; subject 1); (D) Scatter plot representing distribution volumes obtained with image-derived IF (Vt_IDIF) versus distribution volumes obtained with arterial IF (Vt_AIF). S1 to S4 are participants. Distribution volumes were estimated using the Logan graphical analysis method for all Automated Anatomical Labeling brain atlas regions. We could not find any clinical or paraclinical information to explain the difference between S2 and the other volunteers.