Table 2. Biological Assessments and BDI-II scores for the patients with major depression at the time of in-patient admittance and healthy controls.

	Patients with major depression (n = 71)	Healthy controls (n = 48)		Test for differences
BDI-II	Mean: 24.5 SD: 9.7 Median: 24.0 Range: 39	Mean: 1.5 SD: 1.9 Median:1.0 Range: 8		Mann–Whitney-U: 9.5; p <  0.001a Benjamini Hochberg Critical Valuecfor multiple comparisons: 0.017*
TRP, µmol/L	Mean: 60.1 SD: 10.88	Mean: 67.7 SD: 9.50		t: −3.931; df = 116; p< 0.001a Benjamini Hochberg Critical Valuec for multiple comparisons: 0.033*
KYN, µmol/L	Mean: 2.4 SD: 0.62	Mean: 2.5 SD: 0.62		t: −0.945; df = 116; p  =  0.347a Benjamini Hochberg Critical Valuec for multiple comparisons: 0.1*
TRP breakdown to KYN (KYN/TRP Ratio) Spearman rank correlation coefficients between KYN and TRP	Mean: 0.0409 SD: 0.011 Median: 0.040 Range: 0.055 Spearman-Rho:r = 0.253, p = 0.035	Mean: 0.0380 SD: 0.011 Median: 0.035 Range: 0.0628 Spearman-Rho:r =  − 0.005, p = 0.975		Mann–Whitney-U: 1338.0; p  =  0.061a Benjamini Hochberg Critical Valuec for multiple comparisons: 0.067*
QA, nmol/L	Mean: 370.57 SD: 126.12 Median: 348.80 Range: 544.20	Mean: 428.11 SD: 194.96 Median: 390.1 Range: 1049.5		Mann–Whitney-U: 1376.5; p = 0.076a Benjamini Hochberg Critical Valuec for multiple comparisons: 0.083*
KA, nmol/L	Mean: 34.54 SD: 26.08 Median: 30.74 Range: 213.05	Mean: 37.40 SD: 14.61 Median: 34.08 Range: 67.51		Mann–Whitney-U: 1315.0; p = 0.046a Benjamini Hochberg Critical Valuec for multiple comparisons: 0.05d

Notes

^aMann–Whitney-U-test.

^bt-test.

^cBenjamini Hochberg critical value: (i/m)xQ; False Discovery Rate: 0.1.

^dTest significant concerning Benjamin-Hochberg correction.