Table 2. DE miRNAs enriched in P53 signaling pathway.

Categories	miRNA name	Heart	Lung	Target genes in Tarbase
DE in two tissues	miR-192-5p	down	down	CDKN2,MDM2, EI24, PERP, ZMAT3
	miR-32-3p	down	down	MDM4, CDK4, ZMAT3, CCNG1, PPM1D, CASP3
	miR-200b-3p	down	up	MDM4, CCNE1, CDK2, PMAIP1, ZMAT3, SIAH1, DDB2, RCHY1
	miR-146b-5p	up	up	ATR, CDKN1A, THBS1, CCNB3
	miR-122-5p	down	down	MDM4, ATM, TP53, CCNE1, GTSE1, CD262, BCL2L4, CCNG1, TP73, CYCS
DE in heart	miR-200a-3p	down	no	CDKN1A, CCNE1, SIAH1, THBS1, RRM2B
	miR-708-5p	down	no	SESN3, CCNB3
	miR-429	down	no	CDK2, PMAIP1, SIAH1
	miR-885-5p	down	no	CDK2
	miR-194-5p	down	no	TSC2
	miR-708-3p	down	no	CASP3
	miR-208a-3p	down	no	CHK1
	miR-181a-2-3p	down	no	MDM2, CDK4, GTSE1, BCL2L4, SERPINE1
	miR-218-5p	down	no	ATR, ATM, TP53, CDKN1A, CDK4, BCL2L4, ZMAT3, IGFBP3, SERPINE1, SESN3, CCND3, CD262, RCHY1
DE in lung	miR-424-5p	no	up	IGFBP3, RRM2B, SESN3, IGFBP3, CCNG1, SIAH1, MDM2, CHK1, CDKN1A
				CDK4, GTSE1, RFWD2, CD262, PERP, ZMAT3, PPM1D, SCOTIN
	miR-582-5p	no	up	ATR, CDK4, CCND3, PERP, SIAH1, PTEN, CCNG1, SIAH1, CYCS, CCNB3
	miR-34b-5p	no	up	CDKN1A, CDK4, CD262, SIAH1, PPM1D, THBS1
	miR-450b-5p	no	up	MDM2, CDK4, THBS1, SESN3
	miR-34c-5p	no	up	CDK4, STEAP3, SERPINE1
	miR-136-5p	no	up	THBS1
	miR-582-3p	no	up	CDK4, PTEN, CCNB3
	miR-19b-3p	no	up	MDM2,MDM4,ATM,CHK1,TP53,CDKN1A
	miR-379-5p	no	down	SERPINE1, CASP3
	miR-382-5p	no	down	PTEN, TSC2, CASP3
	miR-181c-3p	no	down	MDM2, EI24
	miR-299-5p	no	down	CDKN1A, SERPINE1
	miR-449b-5p	no	down	CDK4, SERPINE1, THBS1, STEAP3
	miR-551b-3p	no	down	ZMAT3
	miR-127-3p	no	down	THBS1
	miR-127-5p	no	down	THBS2
	miR-122-3p	no	down	CD262

Notes.

“Down” indicated downregulated in yak; “up” indicated upregulated in yak, “no” indicated not differently expressed in particular tissue.