Figure 4.

Expression of cell cycle-related proteins and cytoskeletal proteins after RRI and SI treatment. (a) Expression of cyclin B1, cyclin D1 cyclin E1, β-actin, p21, and p53 detected by Q-PCR in MEG-01 cells and MK-PROs. (b) The p53, p21, β-actin, and cyclin B1 expression detected by western blot in MEG-01, UT-7, and MK-PROs. The intensity of each band was digitalized and compared by Image Lab software. (c) Schematic diagram of the relationship of small molecules and cell cycle-related proteins. ^∗p < 0.05; ^∗∗p < 0.01; ^∗∗∗p < 0.001.