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Pulmonary vasodilators drugs, pathways, and mechanisms of action. AC: adenylate cyclase; sGC: soluble guanylate cyclase; ATP and GTP: adenosine and guanosine triphosphate, respectively; cAMP and cGMP: cyclic adenosine and guanosine monophosphate, respectively; inh: inhaled; i.v.: intravenous; NO: nitric oxide; −PDE: phosphodiesterase inhibitor; PK: protein kinase; ⊕: stimulator.
