Table 3.
The univariate Cox regression analysis results for death risk.
| Outcome types | CVD | All causes | ||||||
|---|---|---|---|---|---|---|---|---|
| Covariates | HR | 95% CI | p value | HR | 95% CI | p value | ||
| CD16+ monocytes, % | ||||||||
| Q1(≤3.5 y) versus Q2 | 0.45 | 0.05 | 3.96 | 0.469 | 0.92 | 0.27 | 3.09 | 0.888 |
| Q1(>3.5 y) versus Q2 | 5.16 | 0.56 | 47.86 | 0.149 | 2.00 | 0.53 | 7.63 | 0.308 |
| Q3 versus Q2 | 2.18 | 0.73 | 6.52 | 0.161 | 1.86 | 0.81 | 4.31 | 0.145 |
| Q4 versus Q2 | 5.13 | 1.90 | 13.84 | 0.001∗ | 3.44 | 1.58 | 7.48 | 0.002∗ |
| Sex, male versus female | 0.96 | 0.51 | 1.79 | 0.888 | 0.91 | 0.54 | 1.53 | 0.72 |
| Age, years | 1.03 | 1.01 | 1.06 | 0.011∗ | 1.04 | 1.02 | 1.06 | <0.001∗ |
| HD vintage, years | 0.97 | 0.9 | 1.04 | 0.42 | 0.95 | 0.89 | 1.01 | 0.132 |
| DM, yes versus no | 2.18 | 1.12 | 4.25 | 0.021∗ | 1.87 | 1.09 | 3.2 | 0.023∗ |
| Hypertension, yes versus no | 3.14 | 1.23 | 8.04 | 0.017∗ | 2.16 | 1.09 | 4.27 | 0.027∗ |
| Preexisting CAD, yes versus no | 7.99 | 3.63 | 17.59 | <0.001∗ | 5.66 | 3.11 | 10.3 | <0.001∗ |
| Preexisting CeVD, yes versus no | 2.11 | 1.04 | 4.29 | 0.038∗ | 2.05 | 1.14 | 3.67 | 0.016∗ |
| BMI, kg/m2 | 1.03 | 0.94 | 1.12 | 0.535 | 0.98 | 0.91 | 1.05 | 0.547 |
| WBC, 103/μl | 1.16 | 0.97 | 1.4 | 0.112 | 1.13 | 0.97 | 1.32 | 0.113 |
| Monocyte,103/μl | 1.06 | 0.87 | 1.28 | 0.558 | 1.05 | 0.89 | 1.23 | 0.583 |
| HsCRP, mg/l | 1.49 | 1.15 | 1.91 | 0.002∗ | 1.38 | 1.12 | 1.68 | 0.002∗ |
| FBS, mg/dl | 1.01 | 1 | 1.01 | 0.019∗ | 1.01 | 1 | 1.01 | 0.01∗ |
| rHDL | 4.98 | 0.31 | 80.71 | 0.259 | 4.95 | 0.5 | 48.94 | 0.172 |
| cHDL, mg/dl | 4.98 | 0.31 | 80.71 | 0.259 | 4.95 | 0.5 | 48.94 | 0.172 |
| HbA1c, % | 1.26 | 1.05 | 1.52 | 0.015∗ | 1.21 | 1.04 | 1.42 | 0.015∗ |
| P, mg/dl | 1.06 | 0.84 | 1.34 | 0.606 | 1.01 | 0.83 | 1.22 | 0.945 |
| SBP, mmHg | 1.01 | 1 | 1.03 | 0.171 | 1.01 | 1 | 1.02 | 0.181 |
| DBP, mmHg | 1.01 | 0.98 | 1.05 | 0.43 | 1.01 | 0.98 | 1.04 | 0.521 |
| AbsoMono, cells/μl | 1 | 1 | 1 | 0.121 | 1 | 1 | 1 | 0.127 |
| PLT, 103/μl | 1 | 1 | 1.01 | 0.042∗ | 1 | 1 | 1.01 | 0.133 |
| Ferritin, μg/dl | 1 | 1 | 1 | 0.155 | 1 | 1 | 1 | 0.761 |
| TG, mg/dl | 1 | 1 | 1 | 0.675 | 1 | 1 | 1 | 0.334 |
| HDL, mg/dl | 1 | 0.98 | 1.02 | 0.978 | 1 | 0.98 | 1.01 | 0.84 |
| Cholesterol, mg/dl | 0.99 | 0.98 | 1 | 0.121 | 0.99 | 0.98 | 1 | 0.029∗ |
| rTG | 0.86 | 0.44 | 1.68 | 0.654 | 0.82 | 0.46 | 1.43 | 0.48 |
| Hb, g/dl | 0.89 | 0.7 | 1.13 | 0.348 | 0.92 | 0.76 | 1.12 | 0.405 |
| Albumin, g/dl | 0.23 | 0.06 | 0.85 | 0.028∗ | 0.13 | 0.04 | 0.41 | <0.001∗ |
| BUN, mg/dl | 1 | 0.97 | 1.02 | 0.802 | 0.99 | 0.97 | 1.01 | 0.165 |
| Cr, mg/dl | 0.83 | 0.71 | 0.97 | 0.019∗ | 0.77 | 0.67 | 0.88 | <0.001∗ |
| UA, mg/dl | 0.89 | 0.72 | 1.1 | 0.274 | 0.86 | 0.73 | 1.01 | 0.073 |
| Ca, mg/dl | 0.97 | 0.8 | 1.17 | 0.734 | 0.96 | 0.76 | 1.21 | 0.732 |
Note: the abbreviations are the same as those denoted in Table 1. Q1, Q2, Q3, and Q4 denoted the four ascending classes of the categorical variable which was derived from categorizing each covariate by its three quartiles. The values of the three quartiles were listed in Table 1. Rows indicated as Q1(≤3.5 y) versus Q2 and Q1(>3.5 y) versus Q2 listed the time-varying effect of CD16+ monocytes below the lowest quartile for follow-up time before and after 3.5 years. ∗ indicates p values of less than 0.05.