Figure 5.

Effect of Drynaria rhizome extract (DRE) on the IgE anti-DNP/DNP-HSA-induced passive cutaneous anaphylaxis model. ICR mice were intradermally administered IgE anti-DNP (4 μg/mL) via the ear for 24 h and were then were orally administered DRE (250 or 500 mg/mL) and dexamethasone (10 mg/mL). One hour later, DNP-HSA (300 μg/mL) containing 1% Evans blue was intravenously injected into their tail veins. After 1 h, the extravasated dye in the ears was analyzed using the procedure described in Materials and Methods. Results are expressed as means ± SE of at least five independent experimental results that were tested by analysis of variance with Bonferroni's post hoc testing; ^#p < 0.05, the control group versus the DNP-HSA group; ^∗p < 0.05, the DNP-HSA group versus the DRE and Dex treatment-group.