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. 2017 Oct 22;2017:1089359. doi: 10.1155/2017/1089359

Figure 1.

Figure 1

The vicious cycle of ROS production in cardiac fibroblast. DOX induces ROS production that mediates the activation of TGF-β through its release from LAP. Through its paracrine action, TGF-β induces expression of genes involved in oxidative stress, NOX2, and NOX4, promoting the further increase of ROS.