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Effects of anticancer drugs that induce oxidative stress on endothelial cells. Trastuzumab inhibits HER2/4 pathway, blocking activation of AKT and its regulatory effect on mitochondrial respiration, with consequent ROS accumulation. The latter causes the inhibition of eNOS activity. DOX, is able to directly bind eNOS, inhibiting NO production and inducing RNS and ROS accumulation.
