Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov 7;136(19):1824–1839. doi: 10.1161/CIRCULATIONAHA.117.028110

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

PMC Copyright notice

Figure 3. — Loss of imprinting (LOI) of DLX5 in preeclamptic placenta. A, Analysis of mean LOI levels for DLX5 in healthy and preeclamptic placenta samples. Values are presented as a mean±SEM of LOI (control: 0.1943±0.04765, n=16; early-onset preeclampsia [PE]: 0.5661±0.08516, n=12; late-onset preeclampsia: 0.6349±0.08437, n=14). **P<0.001, ***P<0.0001, 1-way ANOVA, Bonferroni multiple-comparisons test. B, Distribution (number) of DLX5 heterozygocities exceeding a particular LOI. C, Allelic expression analysis of the imprinted DLX5 in placenta samples exhibiting the allele-specific expression but no LOI. cDNA of the heterozygous placenta samples for the single nucleotide polymorphism (rs73708843) were sequenced. D, LOI correlated with DLX5 expression in placenta. P=0.046, Spearman rank correlation. E, CpG methylation of DLX5 locus. Log₂-fold change of CpG methylation level in preeclampsia (control, n=20; early-onset preeclampsia, n=20). Hypomethylated CpG sites are shown (differentially methylated region at adjusted P≤0.05). F, Pairwise Spearman rank correlation of CpG methylation and DLX5 expression in placenta (control, n=8; early-onset preeclampsia, n=8; false discovery rate: *P<0.05, **P<0.01). gDNA indicates genomic DNA.