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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Heart Rhythm. 2017 Jun 10;14(11):1675–1684. doi: 10.1016/j.hrthm.2017.06.018

Figure 6.

Figure 6

Generalization analysis of previously reported HR-associated SNPs. For each SNP, the left-hand darker bar shows a confidence interval (α=5×10-8) for the association (regression estimated β) as reported in 9. The right-hand lighter bar shows a confidence interval (α=0.05/21)) for the association in the Hispanic/Latino meta-analysis. Purple bars are for the eleven SNPs found to generalize to Hispanics/Latinos using the r-value approach; orange bars are for remaining ten SNPs. For the SNPs that generalized, there is evidence that the magnitude of association is similar in Hispanic/Latino compared to European ancestry. In addition, for SNPs that did not generalize, there is no compelling evidence of a different (or null) association in Hispanic/Latino compared to European ancestry populations. Point estimates for Hispanic/Latino associations tend to be attenuated compared to estimates for European ancestry, as expected due to the “winner's curse.”38 For rs2067615, point estimates have opposite sign but confidence intervals are wide and overlap.