Mean fold-change expression values of CNR1, CNR2, FAAH, TRPV1 from whole blood of of cLBP patients (n=42) at baseline (week 1) and week 24. Ct values of each gene of interest was normalised to average of Ct values of 3 housekeeping genes (GAPDH, ACTB and B2M) for each sample. Fold change are presented as mean±S.D. Significant difference in fold-change between groups analyzed paired t-test, *p<0.05 is considered statistically significant.