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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: J Cardiovasc Electrophysiol. 2017 Jun 23;28(9):1070–1082. doi: 10.1111/jce.13259

Figure 4. Effects of V198E/P202L hERG on channel activation and deactivation.

Figure 4

A) Whole cell patch clamp traces of WT hERG and V198E/P202L hERG activation. Voltage clamp protocol shown below trace. B) Current density for WT hERG and V198E/P202L hERG shown in graph form, normalized to cell capacitance. There are no significant differences in current density (n= 8 (WT) and 9 (V198E/P202L hERG)), although there is a trend towards decreased current density in the V198E/P202L hERG. C) Voltage Dependent Activation (VDA) for WT hERG and V198E/P202L hERG shows an identical curve. D) Whole cell patch clamp traces of WT hERG and V198E/P202L hERG deactivation. Voltage clamp protocol shown below trace. N= 2 (WT hERG) and 3 (V198E/P202L hERG). E) Graph of WT and V198E/P202L hERG Slow Tau deactivation and Fast Tau deactivation on a Log10 scale y-axis. There are no differences between WT hERG and V198E/P202L hERG. The V198E/P202L variants do not affect hERG channel deactivation kinetics.