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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: J Cardiovasc Electrophysiol. 2017 Jun 23;28(9):1070–1082. doi: 10.1111/jce.13259

Figure 6. Analysis of LQT2 mutant D219V hERG channel protein abundance.

Figure 6

A) Representative immunoblot of the D219V hERG and WT hERG. B) Summary data comparing total protein expression between WT hERG and D219V hERG, normalized to total protein loaded into the immunoblot, and then normalized to WT hERG. N=4. D219V hERG expresses significantly less protein than WT hERG (p=0.0132) C) Summary data for mature/immature ratio (155kDa/135kDa), or trafficking of hERG for WT hERG and D219V hERG. There are no significant differences in trafficking between these two protein channels