. 2017 May 22;52(11):1495–1503. doi: 10.1038/bmt.2017.56

Table 1. Transthoracic echocardiography.

Two-dimensional and M-mode echocardiography	LV or RV hypertrophy	LV mass index >95 g/m² in women or >115 g/m² in men, or RV free wall thickness in end-diastole >5 mm in the subcostal view.
	RV or LV wall motion abnormalities	Diastolic interventricular septal bounce (sign of ventricular interdependence) or systolic or diastolic septal flattening of the interventricular septum (indicative of RV pressure or volume overload, respectively).
	Significant pericardial effusion	Diameter >1 cm at ventricular end-diastole.
	RV systolic dysfunction	RV fractional area change (apical 4-chamber view (RV end-diastolic area–RV end-systolic area)/RV end-diastolic area) <35% or TAPSE <16 mm.
	LV systolic dysfunction	LV ejection fraction <55%.
Doppler echocardiography	Significant stenotic or regurgitant valvular lesions	Defined as greater than moderate per guideline definitions.^{56, 59}
	Elevated pulmonary artery systolic pressure	>40 mmHg
Pulse wave TDI	TDI evaluation of the RV (tricuspid annulus)	RV TDI s’ velocity <10 cm/s is indicative of RV systolic dysfunction.⁶²
	TDI evaluation of the LV	On the LV side, a lateral s’ velocity <8 cm/s is indicative of LV systolic dysfunction. For evidence of LV diastolic dysfunction on TDI, it is helpful to use age-specific cut-offs of lateral e’ velocity⁶³ which have been used in prior clinical trials: <10 cm/s if aged 45–54 years, <9 cm/s if aged 55–65 years or <8 cm/s if aged >65 years.^{65, 66, 67, 68}

Abbreviations: LV=left ventricle; RV=right ventricle; TAPSE=tricuspid annular plane systolic excursion; TDI= tissue Doppler imaging.