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. 2017 Nov 1;8:218. doi: 10.3389/fpsyt.2017.00218

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Copyright © 2017 Cannella, Cosa-Linan, Roscher, Takahashi, Vogler, Wängler and Spanagel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regional quantification of metabolic activity after infusion of a cocaine bolus (0.8 mg/kg i.v.). (A) Cocaine-induced SUV expressed as relative difference from baseline (i.e., SUV measured after saline injection). Cocaine increased SUV in the mPFM and decreased it in the hypothalamus of cocaine naïve rats. (B) Metabolic maps representing cocaine-induced cerebral metabolic rate of glucose (CMRGlu) in Age Control, 0crit, and 3crit rats. *p < 0.05 vs Age Control, B p < 0.05 and BB p < 0.01 vs Baseline SUV. mPFC, medial prefrontal cortex; Hypoth, hypothalamus.