Table 5. Factors associated with need for intervention - multivariate analysis.

Variable	Sig.	Adjusted OR	95% CI for adjusted OR
Age	0.000	1.076	1.043–1.111
Male sex	0.034	0.401	0.172–0.931
Antibiotic change	0.003	16.916	2.680–106.778
APACHE II score	0.000	0.878	0.820–0.941
ICU stay	0.022	1.287	1.036–1.599

OR, odds ratio; CI, confidence interval; APACHE II, Acute Physiology and Chronic Health Evaluation II; ICU, intensive care unit.