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. 2017 Nov 1;8:777. doi: 10.3389/fphar.2017.00777

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Copyright © 2017 Deng, Xing, Sun, Xu, Wu, Li and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Myocardial fibrosis in MIRI-LVR rats treated with different doses of GXDSF. The immunohistological localization of collagen III (A) and collagen I (B) is shown. Bars represent 50 μm. The relative expression of collagen I and III and the relative ratio of collagen III/I (C) are shown in bar graphs. Masson’s trichrome staining (D) and the percentage of left ventricular fibrosis area (E) are provided. A gel image with an internal reference (α–tubulin) and the relative expression of α–SMA (F; column graph) are shown. Compared with the sham group: ^##P < 0.01, ^###P < 0.001. Compared with the MIRI-LVR model group: ^∗P < 0.05, ^∗∗∗P < 0.001. Compared with the simvastatin group: ^$P < 0.05. The data are presented as the mean ± SD (n = 4 in each group).