Table I. Representative neuropeptides and prohormone-derived peptides identified from rat nucleus accumbens and their corresponding changes induced by food intake. (−0.98) denotes C-terminal amidation. Asterisk denotes significantly changed peptides in response to food intake. Fed/unfed ratio represents the relative level changes of peptides upon feeding. * denotes p < 0.05, ** denotes p < 0.01, and *** denotes p < 0.005.

Gene	Precursor	Accession	Name	Peptide	PTM	-10lgP	m/z	z	Mass	ppm	Fed/unfed Ratio	p value
PCSK1	ProSAAS	Q9QXU9	truncated little SAAS	R.SLSAASAPLAETSTPL.R*		99.00	758.3997	2	1514.7827	1.4	0.45	0.0483
PCSK1	ProSAAS	Q9QXU9	big LEN	R.LENSSPQAPARRLLPP*		84.23	873.4865	2	1744.9584	0	0.42	0.0311
PCSK1	ProSAAS	Q9QXU9	little SAAS	R.SLSAASAPLAETSTPLRL.R***		125.24	892.9910	2	1783.9679	−0.3	0.56	0.0003
PCSK1	ProSAAS	Q9QXU9	PEN	R.AVDQDLGPEVPPENVLGALLRV.K*		133.03	767.7530	3	2300.2375	0.3	0.7	0.0297
PCSK1	ProSAAS	Q9QXU9	Big SAAS	S.ARPVKEPRSLSAASAPLAETSTPLRL.R		120.49	680.3869	4	2717.5188	−0.1	0.71	0.1062
Cartpt	Cocaine- and amphetamine−regulated transcript protein	P49192		R.APGAVLQIEALQEVLKKLKS.K***		107.84	534.5759	4	2134.2725	1	1.46	0.0041
Mch	Pro-MCH	P14200	MCH	R.EIGDEENSAKFPI(−0.98).G	C-term amidation	104.33	724.3575	2	1446.6990	1	n.s.
gal	Galanin peptides	P10683	galanin	R.GWTLNSAGYLLGPHAIDNHRSFSDKHGLT (−0.98).G**	C-term amidation	112.13	633.5222	5	3162.5747	−0.1	0.6	0.0067
Scg2	Secretogranin-2	P10362		R.IPAGSLKNEDTPNRQYLDEDMLLKVLE.Y*		112.21	776.1509	4	3100.5750	−0.2	0.65	0.0194
Chga	Chromogranin-A	P10354		R.WSRMDQLAKELT.A*		89.04	739.3776	2	1476.7395	0.7	1.63	0.0369
Tac3	Tachykinin-3	P08435	Neurokinin B	R.DMHDFFVGLM(−0.98).G	C-term amidation	86.97	605.7739	2	1209.5311	1.7	n.s.
Npy	Pro-neuropeptide Y	P07808	C-flanking peptide of NPY	R.SSPETLISDLLMRESTENAPRTRLEDPSMW		80.38	866.1731	4	3460.6602	0.9	n.s.
Npy	Pro-neuropeptide Y	P07808	Neuropeptide Y	G.YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY(−0.98).G	C-term amidation	122.48	712.5214	6	4269.0811	0.8	n.s.
Tac1	Protachykinin-1	P06767	Neurokinin A	R.HKTDSFVGLM(−0.98).G	C-term amidation	76.02	567.2933	2	1132.5699	1.8	n.s.
Tac1	Protachykinin-1	P06767	substance P	R.RPKPQQFFGLM(−0.98).G	C-term amidation	79.55	674.3711	2	1346.7281	−0.4	n.s.
Tac1	Protachykinin-1	P06767	truncated neuropeptide K	R.DADSSIEKQVALLKALYGHGQISHK.R*		116.99	677.8652	4	2707.4292	0.9	1.51	0.0314
Penk	Proenkephalin-A	P04094	PENK(114–133)	K.MDELYPVEPEEEANGGEILA.K		78.76	1102.9993	2	2203.9829	0.5	n.s.