Table 1.
HPV11E6 Top 10 up- and downregulated gene based on either the extent of up- or downregulation or on their known involvement in cellular transformation.
| Up-regulated |
Down-regulated |
||||
|---|---|---|---|---|---|
| Gene symbol | Gene name | Fold change | Gene symbol | Gene name | Fold change |
| PLAT | Plasminogen activator, tissue | 4.3 | STARD7 | StAR-related lipid transfer domain containing 7 | −4.1 |
| TNFSF10 | Tumor necrosis factor (ligand) superfamily, member 10 | 4.2 | BRCA1 | Breast cancer 1, early onset | −3.1 |
| TP53INP1 | Tumor protein p53 inducible nuclear protein 1 | 4.1 | OR2M7 | Olfactory receptor, family 2, subfamily M, member 7 | −3.0 |
| GADD45A | Growth arrest and DNA-damage-inducible, alpha | 3.8 | IFI6 | Interferon, alpha-inducible protein 6 | −2.4 |
| BUB1 | Budding uninhibited by benzimidazoles 1 | 3.5 | MCM2 | Minichromosome Maintenance complex component 2 | −2.3 |
| BHLHE41 | Basic helix-loop-helix family, member E41 | 3.4 | TMEM27 | Transmembrane protein 27 | −2.2 |
| FBP1 | Fructose-1,6-bisphosphatase 1 | 3.3 | NOX1 | NADPH oxidase 1 | −2.1 |
| LXN | Latexin | 3.1 | JUN | Jun proto-oncogene | −2.1 |
| EPPK1 | Epiplakin 1 | 3.0 | SNAR-E | Small ILF3/NF90-associated RNA E | −2.1 |
| PIGR | Polymeric immunoglobulin receptor | 2.9 | CXCL11 | Chemokine (C-X-C motif) ligand 11 | −2.1 |