Table 2.
HPV18E6 top 10 up- and downregulated genes based on either the extent of up- or downregulation or on their known involvement in carcinogenesis.
| Up-regulated |
Down-regulated |
||||
|---|---|---|---|---|---|
| Gene symbol | Gene name | Fold change | Gene symbol | Gene name | Fold change |
| CEACAM5 | Carcinoembryonic antigen-related cell adhesion molecule 5 | 22.7 | ANKRD1 | Ankyrin repeat domain 1 (cardiac muscle) | −4.8 |
| CYP24A1 | Cytochrome P450, family 24, subfamily A, polypeptide 1 | 13.5 | BCLAF1 | BCL2-associated transcription factor 1 | −4.5 |
| MMP12 | Matrix metalloproteinase 12 | 11.7 | FST | Follistatin | −4.0 |
| GNE | Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 10.2 | TRAJ59 | T cell receptor alpha joining 59 (non-functional) | −4.0 |
| S100A7 | S100 calcium binding protein A7 | 10.0 | PTHLH | Parathyroid hormone-like hormone | −3.9 |
| PNLIPRP3 | Pancreatic lipase-related protein 3 | 9.9 | IFI44L | Interferon-induced protein 44-like | −3.7 |
| FABP4 | Fatty acid binding protein 4, adipocyte | 9.6 | THBS1 | Thrombospondin 1 | −3.3 |
| SERPINB4 | Serpin peptidase inhibitor, clade b (ovalbumin), member 4 | 9.0 | ODC1 | Ornithine decarboxylase 1 | −3.2 |
| AKR1C2 | Aldo-keto reductase family 1, member C2 | 8.4 | ZIC1 | Zinc finger of the cerebellum Family member 1 | −3.2 |
| TRIM31 | Tripartite motif containing 31 | 8.4 | TGFB2 | Transforming growth factor, beta 2 | −3.1 |