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. 2017 Nov 1;11:609. doi: 10.3389/fnins.2017.00609

Figure 1.

Figure 1

Decreased dendritic spine density of MSNs within the striatum commencing from P65-75 in SOD1 mice, compared to WT controls. Images show mosaics of striatum MSNs from P120 WT (A) and SOD1 (B) mice, note our representative image represents the mean MSN dendritic length in 7 of 12 P120 SOD1 mice was decreased compared to the lowest WT value at mid-disease ages. High-magnification images of dendrites from P65-75 WT (C), SOD1 (D), and P120 WT (E), and SOD1 (F) mice MSNs are also shown, with examples of some of the dendritic spines identified using red arrows, representative of the spiny structures and not an exhaustive identification of all quantified spines on these images. (G) shows a scatterplot quantifying unchanged total dendritic arbor length (μm) of SOD1 MSNs (gray squared), compared to WT controls (white circles). (H) shows a scatterplot quantifying significantly decreased dendritic spine density per 100 μm dendrite of SOD1 MSNs (gray squared) compared to WT controls (white circles) at P65-75 and P120. All data mean ± SEM, with two-way ANOVAs followed by Bonferroni post-tests, *P < 0.05 and **P < 0.01. n = 7, 5, 5, and 8 for WT P8-15, P28-35, P65-75, and P120 respectively. n = 6, 5, 5, and 12 for SOD1 P8-15, P28-35, P65-75, and P120 respectively. Scale bar: (A,B), 75 μm. Dendritic frame width (C–F), 20 μm.