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Organization of yeast and human mitochondrial presequence translocases. A and B, yeast, a dimer of single NEF Mge1 maintains import motor function (A), whereas in humans a hetero-oligomeric subcomplex of two NEFs, GrpEL1 and GrpEL2, regulates the mtHsp70 cycle under normal physiological conditions (B). C, the evolution of another stress-resistant NEF GrpEL2 in human mitochondria maintains the import process and organellar homeostasis under stress conditions.
