Figure 8.
Recognition of highly ordered Aβ fibrils required more flexible and dynamic Fabs to transfer the entropy from antibody–antigen complex formation. a, cluster analysis of the structures. Backbone RMSD = 4 Å is used to define the cluster. Clusters are colored blue, red, and gray, respectively. b, motion correlation among the residues of the three Fabs and Aβ fibril. Residues with highly correlated and anti-correlated motion are red and blue. c and d, RMSFs (c) and order parameters S2 (d) of the three Fabs in complex with Aβ fibril. The locations of CDRs and important constant domain loops are boxed. The curves of solanezumab, crenezumab, and CreneFab are colored black, blue, and red, respectively.