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Summary of the properties of the two therapeutic antibodies solanezumab and crenezumab
| Solanezumab | Crenezumab | |
|---|---|---|
| Epitope | Aβ12–28 | Aβ12–23 |
| Aβ form | Monomeric | Monomeric, oligomers, and fibrils |
| Affinity | Picomolar level | Nanomolar level |
| Template | IgG1 | IgG4 |
| CDR-L1 | RSSQSLIYSDGNAYLHTFL | RSSQSLVYSNGDTYLHTYL |
| CDR-L2 | KVSNRFS | KVSNRFS |
| CDR-L3 | SQSTHVPWT | SQSTHVPWT |
| CDR-H1 | GFTFSRYSMS | GFTFSSYGMS |
| CDR-H2 | QINSVGNSTYYPDTVKGRFT | SINSNGGSTYYPDSVKGRFT |
| CDR-H3 | GDY | GDY |
