Table 3.

Binding energy between Fab and Aβ in the forms of monomer, oligomer, and fibrils

The binding energy is calculated by the equation, 〈E_bind〉 = 〈E_complex〉 − 〈E_Fab〉 − 〈E_peptide〉.

Antibody	Aβ chains	Binding energy	Total residue number	Normalized binding energy
		kcal/mol		kcal/mol/residue
Solanezumab	1-mer	−74.3 ± 3.7	451	−0.165
	5-mer	−3.9 ± 4.5	594	−0.007
	16-mer	−41.2 ± 6.3	946	−0.044
Crenezumab	1-mer	−66.0 ± 3.7	451	−0.146
	5-mer	−39.8 ± 4.4	594	−0.067
	16-mer	−195.8 ± 6.3	946	−0.207
Crenezumab chimera	1-mer	−17.8 ± 3.7	451	−0.039
	5-mer	−6.4 ± 4.5	594	−0.011
	16-mer	−85.2 ± 6.0	946	−0.090