Table 1.
Hematologic parameters and serum iron concentrations for wild-type mice (WT) and MT2−/− mice injected with PBS, AAV8-MT2, or AAV8-MT2-mask vectors
Data are expressed as mean ± S.D. Asterisks denote statistically significant differences from the WT group (***, p < 0.001; **, p < 0.01; n ≥ 4).
| WT | MT2−/− + PBS | MT2−/− + AAV8-MT2 | MT2−/− + AAV8-MT2-mask | |
|---|---|---|---|---|
| Hba (g/dl) | 12.80 ± 0.36 | 7.68 ± 0.51*** | 10.80 ± 0.45** | 7.50 ± 0.56*** |
| RBC (106) | 9.24 ± 0.12 | 10.62 ± 0.26*** | 11.96 ± 0.72** | 10.91 ± 0.39*** |
| HCT (%) | 40.80 ± 1.05 | 34.92 ± 1.41*** | 44.43 ± 5.34 | 35.80 ± 1.34** |
| MCV (fl) | 44.50 ± 0.65 | 32.86 ± 0.57*** | 38.96 ± 5.29 | 32.80 ± 0.42*** |
| MCH (pg) | 13.97 ± 0.30 | 7.13 ± 0.25*** | 8.86 ± 0.41*** | 6.86 ± 0.35*** |
| Serum iron (μg/dl) | 109.24 ± 12.88 | 10.96 ± 3.04*** | 122.91 ± 38.16 | 14.57 ± 4.08*** |
a The abbreviations used are: Hb, hemoglobin; RBC, red blood cells; HCT, hematocrit; MCV, mean cell volume; MCH, mean corpuscular hemoglobin.