Skip to main content
. 2017 Oct;142:1–8. doi: 10.1016/j.pestbp.2017.01.007

Fig. 2.

Fig. 2

Effect of GABA and fiprole antagonists on GABA-induced currents in N. lugens RDL receptors functionally expressed in Xenopus oocytes. (A) GABA concentration-response curves on wildtype (WT) and mutant RDL variants carrying an A301S and A301S + Q359E amino acid substitution, respectively. Data are mean values ± SEM (n = 3); (B) Typical example of electrophysiological oocyte recordings showing the concentration-dependent action of GABA (10, 5, 2.5, 1.25, 0.625, 0.313 and 0.156 μM) on functionally expressed receptors (Rdl A301S). (C, D) Antagonist concentration-response curves for fipronil and ethiprole on three different RDL variants. The responses were normalized relative to the currents induced by 5 μM GABA for each receptor variant. Data are mean values ± SEM of 3–5 independent recordings.