Table 2.

In vitro activity of analogues 31–46.

No	R	PARP1 enzyme IC50 (nmol/L)	Cell activity IC50 (nmol/L)a		No	R	PARP1 enzyme IC50 (nmol/L)	Cell activity IC50 (nmol/L)a
			V-C8 (BRCA2−/−)	V79 (BRCA2+/+)				V-C8 (BRCA2−/−)	V79 (s)
1		7.3±0.5	263.6	>10000
31		12.0±4.6			37		7.0±1.1	8579.9	2745.8
32		27.9±11.8			38		2.1±1.7	1585.1	1593.4
33		64.1±25.5			39		5.8±2.2	1108.4	852.5
34		33.9±4.1			40		24.3±7.7
35		6.8±4.8	2916.4	1549.4	41		3.1±1.6	3254.2	>10000
36		3.1±2.3	72.9	568.4	42		10.6±2.7