Table 3. Population pharmacokinetic parameters of MPA computed from population group (n=79)a.
| Parameters | Without covariates | With covariates | ||
|---|---|---|---|---|
| Population mean | IIV [IOV] CV% | Population mean (SE of estimate, %) | IIV [IOV] CV % | |
| CL/F (L/h) | 18.3 (5.19) | 40.6 [23.1] | a=0.0916 (12.7) b=0.0417 (34.3) c=7.98 (7.51) | 34.2 [13.7] |
| V1/F (L) | 26.7 (19.6) | 27.2 [23.1] | a=7.72 (6.85) b=14.7 (15.3) | 21.3 [13.7] |
| k12 (h−1) | 0.839 (27.7) | 31.1 | 0.915 (23.7) | 31.2 |
| k21 (h−1) | 0.057 (21.2) | 132 | 0.059 (15.8) | 138 |
| Ka (h−1) | 1.79 (21.5) | 50.9 | 1.89 (22.7) | 51.3 |
| σϵ1, %; σϵ2, mg/L | 19.7; 0.33 | 15.8; 0.15 | ||
| OFV | 2370 | 2311 | ||
IIV, interindividual variability; IOV, interoccasion variability; SE, standard error; CV%, percentage coefficient of variation; OFV, objective function value.
CL/F=0.0916×BW+0.0417×Scr+7.98=18.3 L/h
V1/F=7.72×UGT2B7 genotype+14.7=27.9 L
aValues in parentheses are the standard error of estimate expressed as coefficient of variation.