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. 2017 Aug 3;38(11):1554–1565. doi: 10.1038/aps.2017.54

Figure 5.

Figure 5

The effects of acute liver failure (ALF) on intestinal permeability and the absorption of zidovudine (AZT) and rhodamine 123 in the jejunum of rats. Plasma fluorescein isothiocyanate-conjugated (FITC) dextran 70 kDa (FD-70) levels (A) and the corresponding AUC of FD-70 (B) were measured 1 and 4 h after oral administration of FD-70 (50 mg/kg) in ALF rats (<0x25CF>, shaded bar) and age-matched control (CON) rats (□, white bar). The accumulative absorption of AZT (C) and rhodamine 123 (E), the corresponding Peff of AZT (D) and rhodamine 123 (F) were measured using an in situ single-pass intestinal perfusion in ALF rats (<0x25CF>, shaded bar) and CON rats (□, white bar), respectively. Data are expressed as mean±SD. n=6. *P<0.05, **P<0.01 vs CON rats.